Integrase

Integrase๋Š” ์ •ํ™•ํ•œ ์œ„์น˜์— ํŠน์ • ์œ ์ „์ž (cargo gene)์„ ์‚ฝ์ž…ํ•˜๋Š” ์—ญํ• ์„ ํ•˜๋Š” ๋‹จ๋ฐฑ์งˆ์ด๋‹ค. ๋Œ€ํ‘œ์ ์œผ๋กœ large serine phage integrase๊ฐ€ ์žˆ์œผ๋ฉฐ, ์ž์—ฐ๊ณ„์— ์กด์žฌํ•˜๋Š” integrase๋Š”...

Integrase๊ฐ€ ์ธ์‹ํ•˜๋Š” ํ‘œ์  (landing sites)์€ integrase ์ข…๋ฅ˜๋งˆ๋‹ค ํŠน์ด์ ์œผ๋กœ์ •ํ•ด์ ธ์žˆ๋‹ค. ์˜ˆ๋ฅผ ๋“ค์–ด, large serine phage integrase๋Š” 30-50nt ๊ธธ์ด์˜ ์—ผ๊ธฐ์„œ์—ด๋กœ ์ด๋ฃจ์–ด์ ธ ์žˆ๋‹ค.

Integrase๊ฐ€ ์ธ์‹ํ•˜๋Š” landing site๋ฅผ ์šฐ๋ฆฌ๊ฐ€ ์›ํ•˜๋Š” ์œ„์น˜์— ์‚ฝ์ž…ํ•ด์ค€๋‹ค๋ฉด, integrase๋ฅผ ์ด์šฉํ•ด large insertion (์ˆ˜ ์ฒœ bp ์ด์ƒ, ๊ฑฐ์˜ ์œ ์ „์ž ๋‹จ์œ„)

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